According to some studies, bicyclic azetidines have the capacity to treat malaria and avoid malaria transmission
Existing antimalarial drugs only treat one stage of the parasite life cycle, and are endangered by the occurrence of resistance.
Researchers curtained 100,000 synthetic compounds with a comprehensive range of 3D features to find out new compounds with action throughout the parasite life cycle, against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum.
The researchers indicated that two compounds in this family could bring a single-dose cure for malaria in mouse models. And one of the compounds, termed BRD7929, was able to remove blood parasites at all stages of the life cycle. The demonstration presented a family of compounds called the bicyclic azetidines.
The findings show that bicyclic azetidines have the potential to both treat malaria and stop malaria transmission as well convenient for prophylaxis in high-risk populations.
Dated: 3rd October 2016